Journal article

Origin of interstitial cells of Cajal mouse intestine

HM Young, D Ciampoli, BR Southwell, DF Newgreen

DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1996

Abstract

The interstitial cells of Cajal (ICC) are found in a number of different locations in the gastrointestinal tract, where they form close associations with both muscle cells and nerve terminals. In this study we examined the embryological origin of ICC in the mouse intestine to determine whether they arise from the neural crest or from the intestinal wall. Segments of intestine were removed from embryonic mice either before or after the arrival of neural crest cells (the precursors of enteric neurons and glial cells) and transplanted under the renal capsule of host (adult) mice and allowed to develop for 18-41 days. In the mouse intestine, antibodies to c-kit protein selectively label ICC at a..

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University of Melbourne Researchers