Paranode Abnormalities and Oxidative Stress in Optic Nerve Vulnerable to Secondary Degeneration: Modulation by 670 nm Light Treatment.
Charis R Szymanski, Wissam Chiha, Natalie Morellini, Nadia Cummins, Carole A Bartlett, Ryan L O'Hare Doig, Donna L Savigni, Sophie C Payne, Alan R Harvey, Sarah A Dunlop, Melinda Fitzgerald
PLoS One | Published : 2013
Secondary degeneration of nerve tissue adjacent to a traumatic injury results in further loss of neurons, glia and function, via mechanisms that may involve oxidative stress. However, changes in indicators of oxidative stress have not yet been demonstrated in oligodendrocytes vulnerable to secondary degeneration in vivo. We show increases in the oxidative stress indicator carboxymethyl lysine at days 1 and 3 after injury in oligodendrocytes vulnerable to secondary degeneration. Dihydroethidium staining for superoxide is reduced, indicating endogenous control of this particular reactive species after injury. Concurrently, node of Ranvier/paranode complexes are altered, with significant length..View full abstract