Journal article
Crystallography and new medicines: Examples from influenza and cell death
PM Colman
Australian Journal of Chemistry | CSIRO PUBLISHING | Published : 2014
DOI: 10.1071/CH14318
Abstract
Biomolecular crystallography underpins contemporary drug discovery. The author's experiences in early (influenza) and recent (cancer) examples mark progress in the sophistication of approaches that have enabled a shift from simpler problems, as in enzyme inhibition, to complex problems, as in blocking protein - protein interactions.
Grants
Funding Acknowledgements
I acknowledge current support from the National Health and Medical Research Centre (NHMRC), the Australian Cancer Research Foundation, the Leukaemia and Lymphoma Society (US), the Victorian State Government Operational Infrastructure Support, and the Australian Government NHMRC IRIISS.