Glucocorticoid-Induced Apoptosis in Animal Models of Multiple Sclerosis
Marco J Herold, Holger M Reichardt
CRITICAL REVIEWS IN IMMUNOLOGY | BEGELL HOUSE INC | Published : 2013
Glucocorticoids (GCs) are highly potent anti-inflammatory and immunosuppressive agents. They exert influence on many cell types of the immune system and impact a plethora of processes such as cytokine production, leukocyte differentiation, migration and adhesion, apoptosis induction, and changes in morphology. Those that are most relevant for the modulation of neuroinflammatory diseases, however, are still under debate. In this review, we will elaborate on how GCs impact inflammatory responses in general and revisit the ambivalent role that apoptosis plays in animal models of multiple sclerosis. Furthermore, we will discuss arguments that speak in favor or against an essential function of GC..View full abstract
Awarded by DFG
Awarded by NHMRC
We would like to thank Dr. Gemma Kelly for language correction. This work was supported by grants from the DFG (Grants No. Re1631/7-1, No. Lu634/8-1, No. SFB-TRR 43 / B13) to HMR, and the Leukaemia Foundation, Australia and NHMRC (Grant No. APP1049720) to MJH.