Ultrasonic fabrication of TiO2/chitosan hybrid nanoporous microspheres with antimicrobial properties

Abstract

We report a sonochemical method for the fabrication of stable TiO2-chitosan hybrid microspheres possessing nanoporous structure and antimicrobial properties. The microspheres were characterized by evaluating their size, surface morphology, and ultrasound-triggered release of encapsulated materials. The size range of the microspheres was found to be in the range 2-20 μm. The antimicrobial activity of TiO2/chitosan microspheres was also evaluated. A possible mechanism for the formation of TiO2-encapsulated chitosan microspheres has been proposed. The methodology demonstrated here can be extended to fabricating nanoparticle or liquid delivery vectors and density controlled catalysts for applica..