Journal article

Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1

Dana B Hancock, Joshua L Levy, Nathan C Gaddis, Cristie Glasheen, Nancy L Saccone, Grier P Page, Gary K Hulse, Dieter Wildenauer, Erin A Kelty, Sibylle G Schwab, Louisa Degenhardt, Nicholas G Martin, Grant W Montgomery, John Attia, Elizabeth G Holliday, Mark McEvoy, Rodney J Scott, Laura J Bierut, Elliot C Nelson, Alex H Kral Show all

Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2015

Grants

Awarded by National Institute of Drug Abuse


Awarded by National Institutes of Health (NIH) Genes, Environment and Health Initiative (GEI)


Awarded by NIH GEI


Awarded by NIH


Awarded by CIDR


Awarded by Collaborative Genetic Study of Nicotine Dependence


Awarded by University of Wisconsin Transdisciplinary Tobacco Use Research Center


Awarded by NIH Office of Research on Women's Health


Awarded by University of Maryland General Clinical Research Center, National Center for Research Resources, NIH


Awarded by National Cancer Institute


Awarded by National Human Genome Research Institute


Awarded by High Density SNP Association Analysis of Melanoma: Case-Control and Outcomes Investigation


Awarded by National Institute on Alcohol Abuse and Alcoholism Grant


Awarded by Australia Government's National Health and Medical Research Council


Awarded by National Institutes of Health, an agency of the United States Department of Health and Human Services


Awarded by National Health and Medical Research Council



Funding Acknowledgements

The BrainCloud dataset used for the expression quantitative trait loci mapping described in this article was obtained from database of Genotypes and Phenotypes (dbGaP) (http://www.ncbi.nlm.nih.gov/gap) via accession number phs000417.v1.p1. Submission of the data to dbGaP was provided by Drs. Barbara Lipska and Joel Kleinman. Collection of the data was through a collaborative study sponsored by the National Institute of Mental Health Intramural Research Program. The BrainCloud applications were downloaded from http://braincloud.jhmi.edu/.This genetic study of heroin addiction cases from the Urban Health Study was supported by the National Institute of Drug Abuse Grant numbers R33 DA027486 and R01 DA026141. Genotyping was conducted at the Center for Inherited Disease Research (CIDR) at Johns Hopkins University.1) Funding support for the Study of Addiction: Genetics and Environment was provided through the National Institutes of Health (NIH) Genes, Environment and Health Initiative (GEI) (U01 HG004422). The Study of Addiction: Genetics and Environment is one of the genome-wide association studies (GWAS) funded as part of the Gene Environment Association Studies (GENEVA) under GEI. Assistance with phenotype harmonization and genotype cleaning, as well as with general study coordination, was provided by the GENEVA Coordinating Center (U01 HG004446). Assistance with data cleaning was provided by the National Center for Biotechnology Information (NCBI). Support for collection of datasets and samples was provided by the Collaborative Study on the Genetics of Alcoholism (U10 AA008401), the Collaborative Genetic Study of Nicotine Dependence (P01 CA089392), and the Family Study of Cocaine Dependence (R01 DA013423). Funding support for genotyping, which was performed at the Johns Hopkins University CIDR, was provided by the NIH GEI (U01HG004438), the National Institute on Alcohol Abuse and Alcoholism, National Institute of Drug Abuse, and the NIH contract "High Throughput Genotyping for Studying the Genetic Contributions to Human Disease" (HHSN268200782096C). The datasets used for the analyses described in this article were obtained via dbGaP accession number phs000092.v1.p1.2) We acknowledge the contribution of data from "Genetic Architecture of Smoking and Smoking Cessation" accessed through dbGaP accession number phs000404.v1.p1. Funding support for genotyping, which was performed at CIDR, was provided by X01 HG005274. CIDR is fully funded through a federal contract from the NIH to The Johns Hopkins University, contract number HHSN268200782096C. Assistance with genotype cleaning, as well as with general study coordination, was provided by the GENEVA Coordinating Center (U01 HG004446). Funding support for collection of datasets and samples was provided by the Collaborative Genetic Study of Nicotine Dependence (P01 CA089392) and the University of Wisconsin Transdisciplinary Tobacco Use Research Center (P50 DA019706 and P50 CA084724).3) Funding support for the GWAS of Ischemic Stroke study was provided through the NIH GEI (U01 HG004436). The GWAS of Ischemic Stroke study is one of the GWAS funded as part of GENEVA under GEI. Assistance with phenotype harmonization and genotype cleaning, as well as with general study coordination, was provided by the GENEVA Coordinating Center (U01 HG004446). Assistance with data cleaning was provided by the NCBI. Funding support for genotyping, which was performed at The Johns Hopkins University CIDR, was provided by the NIH GEI (U01HG004438) and NIH contract number HHSN268200782096C. Field work for this project was supported by a Cooperative Agreement with the Division of Adult and Community Health, Centers for Disease Control and Prevention; the National Institute of Neurological Disorders and Stroke (NINDS) and the NIH Office of Research on Women's Health (R01 NS45012); Office of Research and Development, Medical Research Service, Department of Veterans Affairs; and the University of Maryland General Clinical Research Center (M01 RR165001), National Center for Research Resources, NIH. This study used samples from the NINDS Human Genetics Resource Center DNA and Cell Line Repository (http://ccr.coriell.org/ninds). The datasets used for the analyses described in this article were obtained via dbGaP accession number phs000292.v1.p1.4) Funding support for the GENEVA Prostate Cancer study was provided through the National Cancer Institute (R37 CA54281, R01 CA63464, P01 CA33619, U01 CA136792, U01 CA98758, and RC2 CA148085) and the National Human Genome Research Institute (U01 HG004726). Assistance with phenotype harmonization, single nucleotide polymorphism selection, data cleaning, meta-analyses, data management and dissemination, and general study coordination was provided by the GENEVA Coordinating Center (U01 HG004789). The datasets used for the analyses described in this article were obtained from dbGaP at phs000306.v2.p1.6) For the "High Density SNP Association Analysis of Melanoma: Case-Control and Outcomes Investigation," research support to collect data and develop an application to support this project was provided by P50 CA093459, P50 CA097007, R01 ES011740, and R01 CA133996 (dbGaP accession number phs000187.v1.p1).Two additional cohorts with heroin addiction cases and control subjects were used for replication testing. For the first replication cohort, funding support was provided through the Center for Inherited Disease Research and the Genetics of Alcohol Dependence in American Populations. This CIDR-Gelernter Study is a GWAS funded as part of the "Genetics of Alcohol Dependence in American Populations" cohort, and its investigators provided assistance with phenotype harmonization and genotype cleaning, as well as with general study coordination. Assistance with data cleaning was provided by the NCBI. Support for collection of datasets and samples was provided by the National Institute on Alcohol Abuse and Alcoholism Grant number R01 AA011330. Funding support for genotyping, which was performed at the Johns Hopkins University CIDR, was provided by the NIH GEI (U01 HG004438), the NIAAA, and the NIH contract number HHSN268200782096C. The datasets used for the analyses described in this article were obtained via dbGaP accession number phs000425.v1.p1.The second replication cohort included cases who met lifetime DSM-IV criteria for heroin dependence compared with general population control subjects. Cases and control subjects, many of which are available in dbGaP under "A Genome-Wide Association Study of Heroin Dependence" (accession number phs000277.v1.p1), were derived from the following datasets: 1) The Comorbidity and Trauma Study was funded by National Institute on Alcohol Abuse and Alcoholism Grant number R01 DA17305; 2) The Western Australia Study on Heroin Dependence was funded by the Australia Government's National Health and Medical Research Council (Grant number 513862); 3) The Twin Study of Mole Development in Adolescence (principal investigator [PI]: Nick Martin) was funded by the Australian Government's National Health and Medical Research Council (Grant number 389891); and 4) Support for the Hunter Community Study has been previously described (68). Lastly, GWAS genotyping services for "A Genome-Wide Association Study of Heroin Dependence" at CIDR, located at The Johns Hopkins University, were supported by NIH contract number N01 HG65403.Financial support for this study was provided by the following Grants and contracts by the National Institutes of Health, an agency of the United States Department of Health and Human Services: R33 DA027486 (PI: EOJ), R01 DA026141 (PI: EOJ), R01 DA026911 (PI: NLS), U01 HG004422, U01 HG004446, U10 AA008401, P01 CA089392 (PI: LJB), R01 DA013423 (PI: LJB), R01 DA019963 (PI: LJB), R01 DA025888 (Co-PIs: LJB and EOJ), R01 DA036583 (PI: LJB), U01 HG004438, HHSN268200782096C, X01 HG005274, P50 DA019706, P50 CA084724, U01 HG004436, R01 NS45012, M01 RR165001, R37 CA54281, R01 CA63464, P01 CA33619, U01 CA136792, U01 CA98758, RC2 CA148085, U01 HG004726, U01 HG004789, P50 CA093459, P50 CA097007, R01 ES011740, R01 CA133996, R01 AA011330, R01 DA17305 (PI: ECN), and N01 HG65403. This study was also supported by the Australia Government's National Health and Medical Research Council (Grant number 513862 with PI: SGS and fellowship number 1041742 with PI: LD), National Health and Medical Research Council (Grant number 389891) (PI: NGM), and National Drug and Alcohol Research Centre, which was supported by funding from the Australian Government under the Substance Misuse and Service Improvements Grants Fund.