Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance
Michael J Kraakman, Helene L Kammoun, Tamara L Allen, Virginie Deswaerte, Darren C Henstridge, Emma Estevez, Vance B Matthews, Bronwyn Neill, David A White, Andrew J Murphy, Lone Peijs, Christine Yang, Steve Risis, Clinton R Bruce, Xiao-Jun Du, Alex Bobik, Robert S Lee-Young, Bronwyn A Kingwell, Ajithkumar Vasanthakumar, Wei Shi Show all
Cell Metabolism | CELL PRESS | Published : 2015
Awarded by National Health & Medical Research Council (NHMRC)
Awarded by Deutsche Forschungsgemeinschaft
We thank Mr. Tim Gardner for his technical assistance and Dr. Georg Waetzig for his help with the expression and purification of the sgp130Fc protein. This work was supported by grants from the National Health & Medical Research Council awarded to M.A.F., S.R.-J., and B.A.K. (NHMRC grant no. 526606, APP1041760, APP1036352) and the Victorian Government Operational Infrastructure Support scheme. The work of S.R.-J. was supported by the Deutsche Forschungsgemeinschaft (SFB654, project C5; SFB841, project C1; SFB877, project A1 and the Cluster of Excellence "Inflammation at Interfaces"). M.A.F., B.A.K., A. B., R.S.L.-Y., and C.R.B. are supported by Research Fellowships from the NHMRC. A.K. is supported by a Sylvia and Charles Viertel fellowship. A.J.M. is supported by a Diabetes Australia Research Trust Viertel Award. D.C.H. is supported by a Skip Martin Fellowship of the Australian Diabetes Society. M.J.K. is supported by an Australian Post-Graduate Award and BakerIDI Bright Sparks fellowships.