Characterizing the inhibitory action of zinc oxide nanoparticles on allergic-type mast cell activation
BN Feltis, A Elbaz, PFA Wright, GA Mackay, TW Turney, AL Lopata
MOLECULAR IMMUNOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
The development of nanoparticles (NPs) for commercial products is undergoing a dramatic expansion. Many sunscreens and cosmetics now use zinc oxide (ZnO) or titania (TiO2) NPs, which are effective ultraviolet (UV) filters. Zinc oxide topical creams are also used in mild anti-inflammatory treatments. In this study we evaluated the effect of size and dispersion state of ZnO and TiO2 NPs, compared to "bulk" ZnO, on mast cell degranulation and viability. ZnO and TiO2 NPs were characterized using dynamic light scattering and disc centrifugation. Rat basophilic leukaemia (RBL-2H3) cells and primary mouse bone marrow-derived mast cells (BMMCs) were exposed to ZnO and TiO2 NPs of different sizes (25..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
We would like to acknowledge Micronisers Pty. Ltd. Melbourne, Victoria, Australia for the ZnO NP samples, and the support of the National Health and Medical Research Council (NHMRC) project grant #616621, an Advanced Manufacturing Co-operative Research Centre (AMCRC) research grant, and the Libyan People's Bureau, Canberra. AL is the holder of an Australian Research Council (ARC) Future Fellowship.