Decreased Plasma Iron in Alzheimer's Disease Is Due to Transferrin Desatu ration
Dominic J Hare, James D Doecke, Noel G Faux, Alan Rembach, Irene Volitakis, Christopher J Fowler, Rudolf Grimm, Philip A Doble, Robert A Cherny, Colin L Masters, Ashley I Bush, Blame R Roberts
ACS CHEMICAL NEUROSCIENCE | AMER CHEMICAL SOC | Published : 2015
Plasma iron levels are decreased in Alzheimer's disease (AD) and associated with an idiopathic anemia. We examined iron-binding plasma proteins from AD patients and healthy controls from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing using size exclusion chromatography-inductively coupled plasma-mass spectrometry. Peak area corresponding to transferrin (Tf) saturation was directly compared to routine pathological testing. We found a significant decrease in transferrin-associated iron in AD that was missed by routine pathological tests of transferrin saturation, and that was able to discriminate between AD and controls. The AD cases showed no significant diff..View full abstract
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The University of Technology, Sydney and the University of Melbourne is supported by research funding from the Australian Research Council, the Australian National Health and Medical Research Council and the CRC for Mental Health. The Florey Institute of Neuroscience and Mental Health acknowledges the funding support from the Victorian Government's Operational Infrastructure Support program.