Journal article

ACQUIRED-IMMUNITY TO SALMONELLA-TYPHIMURIUM AND DELAYED (FOOTPAD) HYPERSENSITIVITY IN BALB-C MICE

CE HORMAECHE, MC FAHRENKROG, RA PETTIFOR, J BROCK

IMMUNOLOGY | WILEY | Published : 1981

Abstract

BALB/c mice are extremely susceptible to salmonella infections. Previous reports have suggested that this natural susceptibility is due to a defect in cell-mediated immunity (CMI) which correlates with their inability to develop a delayed (footpad) hypersensitivity reaction to a salmonella extract when immunized with attenuated salmonellae. We have shown that mice thus immunized are in fact highly resistant to superinfecting intravenous challenge with virulent organisms, at a time when the footpad test is still negative. The footpad test becomes positive 2-3 weeks later, after the appearance of CMI, which is already present at 1 week as measured by determining the fate of a superinfecting ch..

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University of Melbourne Researchers