Journal article

Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice

U Greferath, A Bennie, A Kourakis, PF Bartlett, M Murphy, GL Barrett

EUROPEAN JOURNAL OF NEUROSCIENCE | WILEY | Published : 2000

Abstract

The p75 low affinity neurotrophin receptor (p75) can induce apoptosis in various neuronal and glial cell types. Because p75 is expressed in the cholinergic neurons of the basal forebrain, p75 knockout mice may be expected to show an increased number of neurons in this region. Previous studies, however, have produced conflicting results, suggesting that genetic background and choice of control mice are critical. To try to clarify the conflicting results from previous reports, we undertook a further study of the basal forebrain in p75 knockout mice, paying particular attention to the use of genetically valid controls. The genetic backgrounds of p75 knockout and control mice used in this study ..

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University of Melbourne Researchers