Journal article

A proteoglycan that activates fibroblast growth factors during early neuronal development is a perlecan variant

SJ Joseph, MD Ford, C Barth, S Portbury, PF Bartlett, V Nurcombe, U Greferath

DEVELOPMENT | COMPANY OF BIOLOGISTS LTD | Published : 1996

Abstract

Cells in the early embryonic vertebrate nervous system are dependent on members of the fibroblast growth factor (FGF) family for their proliferation and subsequent differentiation. These growth factors will only bind to their specific high affinity cell surface receptors after formation of a ternary complex with the glycosaminoglycan heparan sulfate. Such specific heparan sulfates are secreted as proteoglycans from neural precursor cells and localise to their surfaces. One such proteoglycan, HSPG-PRM (Perlecan-related molecule), was isolated through its ability to potentiate neural cell responses to either FGF-1 or FGF-2. In this study, we have verified the relative molecular mass of the cor..

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University of Melbourne Researchers