Journal article

COMPARISON OF GLYCOLYSIS AND GLUTAMINOLYSIS IN ONCHOCERCA-VOLVULUS AND BRUGIA-PAHANGI BY C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY

NE MACKENZIE, EA VANDEWAA, PR GOOLEY, JF WILLIAMS, JL BENNETT, SM BJORGE, TA BAILLE, TG GEARY

PARASITOLOGY | CAMBRIDGE UNIV PRESS | Published : 1989

Abstract

Comparison of glycolysis in Brugia pahangi and Onchocerca volvulus by 13C nuclear magnetic resonance (NMR) spectroscopy showed that the former organism is predominantly a lactate fermenter and the latter resembles more closely the metabolism of a mixed acid fermenter producing lactate, succinate, acetate, ethanol, formate and carbon dioxide. Both organisms synthesize glycogen as a storage carbohydrate. Glutaminolysis in both organisms proceeds by the delta-amino-butyrate shunt to produce succinate which is then further metabolized to acetate and carbon dioxide as end-products.

University of Melbourne Researchers