Journal article

Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: a case-control and cohort study

Michael Osthoff, Gene-Siew Ngian, Melinda M Dean, Mandana Nikpour, Wendy Stevens, Susanna Proudman, Damon P Eisen, Joanne Sahhar

ARTHRITIS RESEARCH & THERAPY | BMC | Published : 2014

Abstract

INTRODUCTION: Repetitive episodes of ischemia and reperfusion (I/R) are a cardinal feature of the pathogenesis of systemic sclerosis (SSc), which precedes tissue fibrosis. The complement system is a key mediator of tissue damage after I/R, primarily by activation of the lectin pathway. This study investigated whether serum levels and polymorphisms of mannose-binding lectin (MBL) and ficolin-2 (FCN2), two pattern recognition receptors of the lectin pathway, are associated with the predisposition to and clinical features of SSc. METHODS: A case-control study was undertaken involving 90 patients with SSc from a single SSc outpatient clinic and 90 age- and sex-matched blood donors. MBL and FCN2 ..

View full abstract