Colloidally Stabilized Magnetic Carbon Nanotubes Providing MRI Contrast in Mouse Liver Tumors
Yue Liu, Benjamin W Muir, Lynne J Waddington, Tracey M Hinton, Bradford A Moffat, Xiaojuan Hao, Jieshan Qiu, Timothy C Hughes
BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2015
The use of medical imaging contrast agents may lead to improved patient prognosis by potentially enabling an earlier detection of diseases and therefore an earlier initiation of treatments. In this study, we fabricated superparamagnetic iron oxide (SPIO) nanoparticles within the inner cavity of multiwalled carbon nanotubes (MWCNTs) for the first time; thereby ensuring high mechanical stability of the nanoparticles. A simple, but effective, self-assembled coating with RAFT diblock copolymers ensured the SPIO-MWCNTs have a high dispersion stability under physiological conditions. In vivo acute tolerance testing in mice showed a high tolerance dose up to 100 mg kg(-1). Most importantly, after a..View full abstract
Awarded by Australia-China Special Fund
Awarded by NSFC
Awarded by Australian NHMRC
This work was financially supported by Australia-China Special Fund (CH090192) and the NSFC (Nos. U1203292, 21361162004). Y.L. thanks the China Scholarship Council (CSC) and CSIRO for providing scholarships. B.A.M. was supported by the Australian NHMRC (56992, 50932). The authors wish to acknowledge Miss Fengxiang Qie (CSIRO and Beijing University of Chemical Technology), Miss Xuan Nguyen (CMSE, Clayton), and Mr. Marcio Pasotto (CMSE, Clayton) for their help. The authors also acknowledge Barry Halstead for XRD, Yesim Gozukara for ICPMS, Keith Murray and Boujemaa Moubarak for SQUID measurements, and Molecular Imaging In. for animal work and in vivo MRI imaging. The authors thank Dr. Jackie Cai for helpful discussions about the manuscript.