Chondroblastic Osteosarcoma Arising in a Bone Infarct in a Patient with a Prior History of Hodgkin Lymphoma

Abstract

Osteosarcoma is the most common primary bone cancer affecting adolescent and young adults. The majority of osteosarcomas occur sporadically, although increasing age is associated with a higher risk of secondary osteosarcoma. Common causes of secondary osteosarcoma include pre-existing Paget's disease and prior irradiation. Bone infarct-associated sarcoma (IAS) is a rare subset of secondary sarcoma with few reports to date. We present the case of a 28-year-old male who presented with IAS potentially related to previous steroid exposure from treated Hodgkin disease in childhood. He is currently undergoing neoadjuvant chemotherapy with consideration of a limb-sparing surgery after two cycles.