A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Muehlen, Catherine L Kennedy, Kym N Lowes Show all
Nature Communications | NATURE PUBLISHING GROUP | Published : 2015
Awarded by NHMRC
Awarded by ARC
Awarded by Swiss National Science Foundation (SNSF)
Awarded by Novo Nordisk Fonden
We thank Professor R. Flavell for the gift of Ripk2<SUP>-/-</SUP> mice, Professor C. Day for the gift of GST-BIR2 constructs, M. Rashidi for THP-1 NF-kappa B GFP reporter cells and K. Trueman, K. Vella and R. Poppelton for assistance with animal work. The work was supported by the NHMRC (grants 1046986, 461221, 1016701, 1037321, 1043414, 1024839, 1051210, 606788, a CJ Martin fellowship to K.A.J. and J.H., a Peter Doherty Early Career Fellowship (1035502) to L.M.L. and research fellowships to J.S., J.V., M.W.P., A.M.L. and D.C.S.H.), the ARC (fellowships to U.N. (FT130100166), C.L.K. (DE12010340) and J.M.M. (FT 100100100)), the WEHI de Burgh Fellowship to G.L., the Rebecca Cooper Foundation, the Juvenile Diabetes Research Foundation, the Leukaemia and Lymphoma Society, the Australian Cancer Research Foundation, Catalyst Therapeutics, the Novo Nordisk Foundation (MGH, BKF) and the Lundbeck Foundation (MGH). U.N. was also supported by the Swiss National Science Foundation (SNSF, fellowship #PA00P3_126249). M.G.-H. was supported by a Steno Fellowship from the Danish Council for Independent Research-Natural Sciences. J.K.H. is supported by a joint Cure Cancer/Leukemia Foundation Fellowship. L.M.L. is a Bisby Fellow and thanks the CIHR for a Post-PhD Fellowship. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS (#361646).