The role of estrogen in the treatment of men with schizophrenia.
Jayashri Kulkarni, Emmy Gavrilidis, Roisin Worsley, Tamsyn Van Rheenen, Emily Hayes
Int J Endocrinol Metab | Published : 2013
Schizophrenia is a debilitating and pervasive mental illness with devastating effects on many aspects of psychological, cognitive and social wellbeing. Epidemiological and life-cycle data point to significant differences in the incidence and course of schizophrenia between men and women, suggesting that estrogen plays a "protective" role . Adjunctive estrogen therapy has been shown to be effective in enhancing the treatment of schizophrenia in women. In men, consideration of estrogen therapy has been impacted by concerns of feminisation, however, clinical trials using estrogen to treat prostate cancer, bone density loss and even aggression in men with dementia or traumatic brain injury, show..View full abstract