Widespread changes of white matter microstructure in obsessive-compulsive disorder: Effect of drug status
Francesco Benedetti, Chiara Giacosa, Daniele Radaelli, Sara Poletti, Elena Pozzi, Sara Dallaspezia, Andrea Falini, Enrico Smeraldi
EUROPEAN NEUROPSYCHOPHARMACOLOGY | ELSEVIER SCIENCE BV | Published : 2013
Diffusion tensor imaging (DTI) allows the study of white matter (WM) structure. Literature suggests that WM structure could be altered in obsessive-compulsive disorder (OCD) proportional to the severity of the disease. Heterogeneity of brain imaging methods, of the studied samples, and of drug treatments make localization, nature, and severity of the WM abnormalities unclear. We applied Tract-Based Spatial Statistics (TBSS) of DTI measures to compare fractional anisotropy (FA), mean, axial, and radial diffusivity of the WM skeleton in a group of 40 consecutively admitted inpatients affected by severe OCD (18 drug-naive, and 22 with an ongoing drug treatment) and 41 unrelated healthy voluntee..View full abstract
Awarded by European Union
The C.E.R.M.A.C. received research Grants from the Italian Ministry of University and Scientific Research, from the Italian Ministry of Health, from the European Union (FP7 Grant 222963), from Trenta ore per la Vita Association, and from Janssen-Cilag.