Journal article

Caudate Gray Matter Volume in Obsessive-Compulsive Disorder Is Influenced by Adverse Childhood Experiences and Ongoing Drug Treatment

Francesco Benedetti, Sara Poletti, Daniele Radaelli, Elena Pozzi, Chiara Giacosa, Chiara Ruffini, Andrea Falini, Enrico Smeraldi

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012

Abstract

BACKGROUND: Exposure to adverse childhood experiences (ACE) increases the risk of adult physical and mental health disorders, including obsessive-compulsive disorder (OCD), and influences adult cortical neural responses and gray matter (GM) volumes. Robust neuroimaging findings associated OCD with corticostriatal dysfunction and with abnormal morphology and metabolism of cortical areas and basal ganglia. METHODS: We explored the GM correlates of ACE in 40 patients with OCD (15 drug-naive and 25 drug-treated patients) with magnetic resonance imaging voxel-based morphometry at 3.0 T. Regional GM volumes were the dependent variable, and drug treatment (naive vs treated) and breadth of exposure ..

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University of Melbourne Researchers