Caudate Gray Matter Volume in Obsessive-Compulsive Disorder Is Influenced by Adverse Childhood Experiences and Ongoing Drug Treatment
Francesco Benedetti, Sara Poletti, Daniele Radaelli, Elena Pozzi, Chiara Giacosa, Chiara Ruffini, Andrea Falini, Enrico Smeraldi
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012
BACKGROUND: Exposure to adverse childhood experiences (ACE) increases the risk of adult physical and mental health disorders, including obsessive-compulsive disorder (OCD), and influences adult cortical neural responses and gray matter (GM) volumes. Robust neuroimaging findings associated OCD with corticostriatal dysfunction and with abnormal morphology and metabolism of cortical areas and basal ganglia. METHODS: We explored the GM correlates of ACE in 40 patients with OCD (15 drug-naive and 25 drug-treated patients) with magnetic resonance imaging voxel-based morphometry at 3.0 T. Regional GM volumes were the dependent variable, and drug treatment (naive vs treated) and breadth of exposure ..View full abstract
Awarded by European Union
The CERMAC received research grants from the following: Italian Ministry of University and Scientific Research, Italian Ministry of Health, European Union (FP7 grant 222963), Trenta ore per la Vita Association, and Janssen-Cilag.