Growth Kinetics and Transmission Potential of Existing and Emerging Field Strains of Infectious Laryngotracheitis Virus
Sang-Won Lee, Carol A Hartley, Mauricio JC Coppo, Paola K Vaz, Alistair R Legione, Jose A Quinteros, Amir H Noormohammadi, Phillip F Markham, Glenn F Browning, Joanne M Devlin
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
Attenuated live infectious laryngotracheitis virus (ILTV) vaccines are widely used in the poultry industry to control outbreaks of disease. Natural recombination between commercial ILTV vaccines has resulted in virulent recombinant viruses that cause severe disease, and that have now emerged as the dominant field strains in important poultry producing regions in Australia. Genotype analysis using PCR-restriction fragment length polymorphism has shown one recombinant virus (class 9) has largely replaced the previously dominant class 2 field strain. To examine potential reasons for this displacement we compared the growth kinetics and transmission potential of class 2 and class 9 viruses. The ..View full abstract
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Awarded by Australian Research Council
Funding provided by Australian Research Council DP130103991 (http://www.arc.gov.au). The funders (Australian Research Council) had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Rural Industries Research and Development Corporation PRJ-008792 (http://www.rirdc.gov.au). The funders (RIRDC) had contributed to study design and approved publication of the manuscript but did not have any role in data collection and analysis or the preparation of the manuscript.