Journal article
GM-CSF as a target in inflammatory/autoimmune disease: Current evidence and future therapeutic potential
JA Hamilton
Expert Review of Clinical Immunology | Published : 2015
Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF) can be viewed as a pro-inflammatory cytokine rather than as a key regulator of steady state and systemic myelopoiesis. Key aspects of GM-CSF biology need to be clarified such as pro-survival vs activation/differentiation function, its cellular sources, its responsive cell populations, its downstream mediators/pathways, and when GM-CSF is relevant. Striking effects of GM-CSF depletion/deletion in some pre-clinical autoimmune/inflammation models have been reported. Systemic effects of administered GM-CSF are not necessarily informative about its local blockade in disease. Recent clinical RA trials, particularly Phase II trials with mavr..
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Funding Acknowledgements
JA Hamilton is employed by The University of Melbourne. The University of Melbourne has licensed patented technology relating to therapeutically targeting GM-CSF to MorphoSys AG, Germany. JA Hamilton has consultancies with GSK and CSL Pty Ltd amounting to less than $10,000 per year per entity. This work was supported by a Senior Principal Research Fellowship from the National Health and Medical Research Council of Australia. Rifa Sallay is acknowledged for typing the manuscript. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.