Journal article

Extremes of Age Are Associated with Indeterminate QuantiFERON-TB Gold Assay Results

Marc Tebruegge, Hans de Graaf, Priya Sukhtankar, Paul Elkington, Ben Marshall, Helmut Schuster, Sanjay Patel, Saul N Faust

JOURNAL OF CLINICAL MICROBIOLOGY | AMER SOC MICROBIOLOGY | Published : 2014

Abstract

Results from 3,263 QuantiFERON-TB Gold in-tube (QFT-GIT) assays were analyzed to determine the impact of age on test performance. The proportion of indeterminate results was significantly higher in pediatric and elderly (9.1% and 7.4%, respectively) than in adult (2.6%; chi-square test, P < 0.0001) patients. A detailed analysis of indeterminate QFT-GIT assay results is presented.

Grants

Awarded by National Institute for Health Research


Funding Acknowledgements

M. T. is supported by a Clinical Lectureship provided by the United Kingdom National Institute for Health Research and a research grant provided by the United Kingdom Technology Strategy Board. M. T., P. E., and S. N. F. are supported by the Southampton NIHR Respiratory Biomedical Research Unit. S. N. F., H. D. G., and P. S. are supported by the Southampton NIHR Wellcome Trust Clinical Research Facility.