Journal article

Chronological analysis of gross and histological lesions induced by field strains of fowl adenovirus serotypes 1, 8b and 11 in one-day-old chickens

Penelope A Steer, Jeanine R Sandy, Denise O'Rourke, Peter C Scott, Glenn F Browning, Amir H Noormohammadi



Fowl adenoviruses (FAdVs) cause diseases in domestic chickens, including inclusion body hepatitis (IBH), with immunosuppression believed to play a role in their pathogenesis. To gain a better understanding of the pathogenesis and chronology of disease caused by FAdVs, the gross pathology, histopathology and dissemination of virus were examined at several different time points, after inoculation of one-day-old specific pathogen-free chickens with FAdV-1, FAdV-8b or FAdV-11 via the ocular route. FAdV-8b had a slightly greater virulence than FAdV-11, but both were primary pathogens. The presence and severity of hepatic lesions were used to define the three stages of the disease: incubation (1-3..

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Funding Acknowledgements

This research was partly conducted within the Poultry Cooperative Research Centre, established and supported under the Australian Government's Cooperative Research Centres Program. The primary author was supported by scholarships from The University of Melbourne and the Poultry Cooperative Research Centre. The authors would like to thank Garry Anderson for assistance with statistical analyses, Kylie Hewson, Anthony Chamings and Mauricio Coppo for technical assistance, and Cheryl Colson, June Daly and Jenece Wheeler for assistance with animal experiment procedures.