The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V
Michelle Gazdik, Matthew T O'Neill, Sash Lopaticki, Kym N Lowes, Brian J Smith, Alan F Cowman, Justin A Boddey, Brad E Sleebs
MedChemComm | ROYAL SOC CHEMISTRY | Published : 2015
Awarded by National Health and Medical Research Council of Australia
Awarded by CASS Foundation Science and Medicine grant
This work was funded by the National Health and Medical Research Council of Australia (Project Grant 1010326 to J.A.B), a CASS Foundation Science and Medicine grant (SM.12.4348 to JAB), the Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. We thank the University of Melbourne for the provision of an Australian Postgraduate Award to M.G. A.F.C. is a Howard Hughes International Scholar and an Australia Fellow of the NHMRC. J.A.B is an Australian Research Council QEII Fellow. We thank Guillaume Lessene, Janet Weinstock and Andrew Powell for useful discussions.