Journal article

PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML

Tom Verbiest, Simon Bouffler, Stephen L Nutt, Christophe Badie

CARCINOGENESIS | OXFORD UNIV PRESS | Published : 2015

Abstract

The transcription factor PU.1, encoded by the murine Sfpi1 gene (SPI1 in humans), is a member of the Ets transcription factor family and plays a vital role in commitment and maturation of the myeloid and lymphoid lineages. Murine studies directly link primary acute myeloid leukaemia (AML) and decreased PU.1 expression in specifically modified strains. Similarly, a radiation-induced chromosome 2 deletion and subsequent Sfpi1 point mutation in the remaining allele lead to murine radiation-induced AML. Consistent with murine data, heterozygous deletion of the SPI1 locus and mutation of the -14kb SPI1 upstream regulatory element were described previously in human primary AML, although they are r..

View full abstract

University of Melbourne Researchers

Grants

Awarded by European Union FP7 EURATOM DoReMi network of excellence


Awarded by Risk, Stem Cells and Tissue Kinetics-Ionising Radiation


Funding Acknowledgements

European Union FP7 EURATOM DoReMi network of excellence (249689 to C.B. and S.B.), Risk, Stem Cells and Tissue Kinetics-Ionising Radiation (323267 to C.B. and S.B.), an Australian Research Council Future Fellowship (S.L.N.), Victorian State Government Operational Infrastructure Support, Australian Government NHMRC IRIIS (S.L.N.) and the National Institute for Health Research Centre for Health Protection Research.