Journal article
Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury
Sandy R Shultz, David K Wright, Ping Zheng, Ryan Stuchbery, Shi-Jie Liu, Maithili Sashindranath, Robert L Medcalf, Leigh A Johnston, Christopher M Hovens, Nigel C Jones, Terence J O'Brien
BRAIN | OXFORD UNIV PRESS | Published : 2015
DOI: 10.1093/brain/awv053
Abstract
Traumatic brain injury is a common and serious neurodegenerative condition that lacks a pharmaceutical intervention to improve long-term outcome. Hyperphosphorylated tau is implicated in some of the consequences of traumatic brain injury and is a potential pharmacological target. Protein phosphatase 2A is a heterotrimeric protein that regulates key signalling pathways, and protein phosphatase 2A heterotrimers consisting of the PR55 B-subunit represent the major tau phosphatase in the brain. Here we investigated whether traumatic brain injury in rats and humans would induce changes in protein phosphatase 2A and phosphorylated tau, and whether treatment with sodium selenate-a potent PR55 activ..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Victorian Transport Accident Commission (Victorian Neurotrauma Initiative Grant)
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This study was funded by grants to T.O., C.H., N.J., M.S. and S.S. from the National Health and Medical Research Council (NHMRC #1006077 and #1062653), the Victorian Transport Accident Commission (Victorian Neurotrauma Initiative Grant #DNP13), the Alzheimer's Australia Dementia Research Fund, the Royal Melbourne Hospital Neuroscience Foundation, and the Canadian Institute of Health Research. Human brain tissues were received from the Victorian Brain Bank Network, supported by the Mental Health Research Institute, The Alfred, Victorian Forensic Institute of Medicine, The University of Melbourne and funded by NHMRC, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services.