Candida infective endocarditis: An observational cohort study with a focus on therapy

CJ Arnold; M Johnson; AS Bayer; S Bradley; E Giannitsioti; JM Miró; P Tornos; P Tattevin; J Strahilevitz; D Spelman; E Athan; F Nacinovich; CQ Fortes; C Lamas; B Barsic; N Fernández-Hidalgo; P Muñoz; VH Chu; L Clara; M Sanchez; J Casabé; C Cortes; PF Oses; R Ronderos; A Sucari; J Thierer; J Altclas; S Kogan; O Harris; K Kennedy; R Tan; D Gordon; L Papanicolas; T Korman; D Kotsanas; R Dever; P Jones; P Konecny; R Lawrence; D Rees; S Ryan; MP Feneley; J Harkness; J Post; P Reinbott; R Gattringer; F Wiesbauer; AR Andrade; ACP De Brito; AC Guimarães; M Grinberg; AJ Mansur; RF Siciliano; TMV Strabelli; MLC Vieira; RA De Medeiros Tranchesi; MG Paiva; A De Oliveira Ramos; C Weksler; G Ferraiuoli; W Golebiovski; JA Karlowsky; Y Keynan; AM Morris; E Rubinstein; SB Jones; P Garcia; M Cereceda; A Fica; RM Mella; R Fernandez; L Franco; J Gonzalez; AN Jaramillo; S Bukovski; V Krajinovic; A Pangercic; I Rudez; J Vincelj; T Freiberger; J Pol; B Zaloudikova; Z Ashour; AE Kholy; M Mishaal; D Osama; H Rizk; N Aissa; C Alauzet; F Alla; C Campagnac; T Doco-Lecompte; C Selton-Suty; JP Casalta; PE Fournier; G Habib; D Raoult; F Thuny; F Delahaye

Journal article

Candida infective endocarditis: An observational cohort study with a focus on therapy

CJ Arnold, M Johnson, AS Bayer, S Bradley, E Giannitsioti, JM Miró, P Tornos, P Tattevin, J Strahilevitz, D Spelman, E Athan, F Nacinovich, CQ Fortes, C Lamas, B Barsic, N Fernández-Hidalgo, P Muñoz, VH Chu, L Clara, M Sanchez Show all

Antimicrobial Agents and Chemotherapy | Published : 2015

DOI: 10.1128/AAC.04867-14

Abstract

Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous ..

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University of Melbourne Researchers

Eugene Athan Author

Grants

Funding Acknowledgements

Funding for this study was provided, in part, by the American Heart Association (AHA 0675027N) and an educational grant from Merck (Vivian H. Chu).Melissa Johnson receives research support from Charles River Laboratories, Astellas Pharma US, and WHISCON as well as royalties from UpToDate. Arnold S. Bayer receives research funding from Cubist Pharmaceuticals, Contrafect Pharmaceuticals, and Theravance Pharmaceuticals and a grant from the NIH (NIH-NIAID RO-1). Pierre Tattevin receives travel grants from Astellas, Gilead, MSD, and Pfizer. Bruno Barsic is on the Board of Speakers for Pfizer, MSD, Astellas, and Pliva. Jose Miro receives consulting honoraria and research grants from AbbVie, Bristol Myers Squibb, Cubist, Novartis, Gilead, Pfizer, and ViiV.