Journal article

Effectiveness of short-course quinine and singledose sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria in Mpumalanga province, South Africa

E Athan, DN Durrheim, K Barnes, NM Mngomezulu, A Mabuza, J Govere

SOUTH AFRICAN MEDICAL JOURNAL | MED ASSOC S AFRICA | Published : 2001

Abstract

INTRODUCTION: Quinine therapy for 7 days remains the mainstay for treating hospitalised malaria cases in South Africa. However, limited resources, including available beds and staff, often result in early discharge of non-severe cases, with quinine tablets for outpatient use. The effectiveness of shorter course quinine therapy coupled with a long-acting antimalarial drug has never been established in Africa, in particular in a population without malaria immunity. METHODS: A study was conducted to evaluate the effectiveness of a 3-day course of therapy with quinine sulphate (10 mg/kg 8-hourly) followed by a single dose of sulfadoxine-pyrimethamine (SP) according to weight category, before dis..

View full abstract

University of Melbourne Researchers