HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort

ST Chambers; DR Murdoch; A Morris; D Holland; P Pappas; M Almela; N Ferna´ndez-Hidalgo; B Almirante; E Bouza; D Forno; A del Rio; MM Hannan; J Harkness; ZA Kanafani; T Lalani; S Lang; N Raymond; K Read; T Vinogradova; CW Woods; D Wray; GR Corey; VH Chu; L Clara; M Sanchez; F Nacinovich; PF Oses; R Ronderos; A Sucari; J Thierer; J Casabe´; C Cortes; J Altclas; S Silvia Kogan; D Spelman; E Athan; O Harris; K Kennedy; R Tan; D Gordon; L Papanicolas; D Eisen; L Grigg; A Street; T Korman; D Kotsanas; R Dever; P Jones; P Konecny; R Lawrence; D Rees; S Ryan; MP Feneley; J Post; P Reinbott; R Gattringer; F Wiesbauer; AR Andrade; ACP de Brito; AC Guimara~es; M Grinberg; AJ Mansur; RF Siciliano; TMV Strabelli; MLC Vieira; RA de Medeiros Tranchesi; MG Paiva; CQ Fortes; A de Oliveira Ramos; G Ferraiuoli; W Golebiovski; C Lamas; M Santos; C Weksler; JA Karlowsky; Y Keynan; AM Morris; E Rubinstein; SB Jones; P Garcia; M Cereceda; A Fica; RM Mella; B Barsic; S Bukovski; V Krajinovic; A Pangercic; I Rudez; J Vincelj; T Freiberger; J Pol; B Zaloudikova; Z Ashour; AE Kholy; M Mishaal; H Rizk; N Aissa; C Alauzet; F Alla; C Campagnac

Journal article

HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort

ST Chambers, DR Murdoch, A Morris, D Holland, P Pappas, M Almela, N Ferna´ndez-Hidalgo, B Almirante, E Bouza, D Forno, A del Rio, MM Hannan, J Harkness, ZA Kanafani, T Lalani, S Lang, N Raymond, K Read, T Vinogradova, CW Woods Show all

Plos One | Published : 2013

DOI: 10.1371/journal.pone.0063181

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Abstract

The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 ..

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University of Melbourne Researchers

Eugene Athan Author

Andrew Wang Author

Grants

Awarded by American Heart Association

Awarded by Spanish Network for Research in Infectious Diseases

Awarded by American Heart Association (AHA)

Funding Acknowledgements

This work was supported by the American Heart Association 0675027N (VHC), educational grants from International Society of Cardiovascular Infectious Diseases, International Society of Chemotherapy, the "Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III'', Madrid, Spain, and the Spanish Network for Research in Infectious Diseases (REIPI RD06/0008) (MA, CGDM) and the Fundacion Privada Maximo Soriano Jimenez (Barcelona, Spain) (CGDM). The funders had no role in study design, data collection adn analysis, decision to publish, or preparation of the manuscript.