Non-Aβ component of Alzheimer's disease amyloid (NAC) revisited: NAC and α-Synuclein are not associated with Aβ amyloid

Abstract

α-Synuclein (αSN), also termed the precursor of the non-Aβ component of Alzheimer's disease (AD) amyloid (NACP), is a major component of Lewy bodies and Lewy neurites pathognomonic of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). A fragment of αSN termed the non-Aβ component of AD amyloid (NAC) had previously been identified as a constituent of AD amyloid plaques. To clarify the relationship of NAC and αSN with Aβ plaques, antibodies were raised to three domains of αSN. All antibodies produced puncrate labeling of human cortex and strong labeling of Lewy bodies. Using antibodies to αSN(75-91) to label cortical and hippocampal sections of pathologically proven AD cases, we fou..