Journal article

Systematic Detection of Familial Hypercholesterolaemia in Primary Health Care: A Community Based Prospective Study of Three Methods

Andrew B Kirke, Rita A Barbour, Sally Burrows, Damon A Bell, Alistair W Vickery, Jon Emery, Gerald F Watts

Heart Lung and Circulation | ELSEVIER SCIENCE INC | Published : 2015


BACKGROUND: Familial hypercholesterolaemia (FH), a co-dominantly inherited disease of cholesterol that markedly increases risk of premature coronary artery disease (CAD), is significantly under-diagnosed. Primary health care is increasingly seen as a setting in which to increase the detection rate of index cases. We report a prospective study of three methods of case detection using pre-existing primary health care services in one community. METHODS: Three methods of case detection were tested: pathology laboratory database search, workplace health checks and general practice database search. People identified at risk by each of the three screening methods were offered detailed assessment fo..

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University of Melbourne Researchers


Funding Acknowledgements

We acknowledge Val Lishman Heath Research Foundation (VLHRF), Royalties for Regions and LotteryWest funding grants, Rural Clinical School Western Australia (RCSWA) for staff and research support, Familial Hypercholesterolaemia Western Australia (FHWA) for staff and research support, Australian Better Health Initiative (ABHI) for funding FHWA, general practices Dalyellup Family Medical Practice and Eaton Medical Practice, community pathology laboratories Bunbury Pathology, St John of God Health Care and Healthscope, Royal Perth Hospital (RPH) for clinical follow up of patients, Pathwest for clinical testing of referred high-risk patients, Edith Cowan University, Bunbury campus, for office space. Professor Campbell Murdoch and Dr Keith Howe were instrumental in setting up the study, organising the research partners, funding and ethics approval. Research nurses Lucia Buoro and Lara Hawking completed the patient face-to-face assessments.