Cytokines for monitoring anti-tuberculous therapy: A systematic review
Vanessa Clifford, Christel Zufferey, Alan Street, Justin Denholm, Marc Tebruegge, Nigel Curtis
TUBERCULOSIS | CHURCHILL LIVINGSTONE | Published : 2015
The ability to monitor response to therapy for tuberculosis (TB) and confirm adequate treatment would be a major advance. The low reversion rate of interferon-gamma based assays means that they are unlikely to be useful for monitoring therapy. Several exploratory studies have evaluated the diagnostic potential of cytokine biomarkers other than interferon-gamma for monitoring anti-tuberculous therapy. A systematic review of these studies was performed to identify the most promising candidate biomarkers. TNF-α, IL-2, IL-6, IL-10 and IL-12 were the most extensively investigated cytokines. There was significant heterogeneity between studies in relation to study design and laboratory methodology,..View full abstract
Awarded by John Burge Trust
Awarded by National Institute for Health Research
The study was partially supported by a grant from the John Burge Trust 1203 (2013); MT is supported by a Clinical Lectureship provided by the U.K. National Institute for Health Research.