Journal article
Cytokines for monitoring anti-tuberculous therapy: A systematic review
Vanessa Clifford, Christel Zufferey, Alan Street, Justin Denholm, Marc Tebruegge, Nigel Curtis
TUBERCULOSIS | CHURCHILL LIVINGSTONE | Published : 2015
Abstract
The ability to monitor response to therapy for tuberculosis (TB) and confirm adequate treatment would be a major advance. The low reversion rate of interferon-gamma based assays means that they are unlikely to be useful for monitoring therapy. Several exploratory studies have evaluated the diagnostic potential of cytokine biomarkers other than interferon-gamma for monitoring anti-tuberculous therapy. A systematic review of these studies was performed to identify the most promising candidate biomarkers. TNF-α, IL-2, IL-6, IL-10 and IL-12 were the most extensively investigated cytokines. There was significant heterogeneity between studies in relation to study design and laboratory methodology,..
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Awarded by John Burge Trust
Awarded by National Institute for Health Research
Funding Acknowledgements
The study was partially supported by a grant from the John Burge Trust 1203 (2013); MT is supported by a Clinical Lectureship provided by the U.K. National Institute for Health Research.