The genetic control of avascular area in mouse oxygen-induced retinopathy
Bliss E O'Bryhim, Jeff Radel, Stuart J Macdonald, RC Andrew Symons
MOLECULAR VISION | MOLECULAR VISION | Published : 2012
PURPOSE: The C57BL/6ByJ and BALB/cByJ inbred strains of mice are, respectively, susceptible and resistant to oxygen-induced retinopathy (OIR). The purpose of this work was to investigate the genetic control of the retinal avascular area in mouse OIR using a mapping cross. METHODS: The central retinal avascular area was measured on postnatal day 16 (P16) in C57BL/6ByJ, BALB/cByJ, 101 (C57BL/6ByJ x BALB/cByJ)F₂, and 116 (BALB/cByJ x C57BL/6ByJ)F₂ mice that had been subjected to the OIR protocol. A genome-wide scan was performed of selected albino and non-albino mice to determine quantitative trait loci associated with weight and avascular area. RESULTS: C57BL/6ByJ mice had significantly larger..View full abstract
Awarded by COBRE
Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES
This work was supported by the Kansas Lions Sight Foundation and the Knights Templar Eye Foundation. Use of the Thermo Scientific NanoDrop for measurement of DNA concentrations before SNP analysis was supported by COBRE grant 2 P20RR021940. Bliss O'Bryhim was supported by the Myrtle R. and Emmit Eugene Peterson Memorial Fund.