Journal article
Neurodevelopmental outcomes at 7 years' corrected age in preterm infants who were fed high-dose docosahexaenoic acid to term equivalent: A follow-up of a randomised controlled trial
CT Collins, RA Gibson, PJ Anderson, AJ McPhee, TR Sullivan, JF Gould, P Ryan, LW Doyle, PG Davis, JE McMichael, NP French, PB Colditz, K Simmer, SA Morris, M Makrides
BMJ Open | Published : 2015
Abstract
Objective: To determine if improvements in cognitive outcome detected at 18 months' corrected age (CA) in infants born <33 weeks' gestation receiving a high-docosahexaenoic acid (DHA) compared with standard-DHA diet were sustained in early childhood. Design: Follow-up of a multicentre randomised controlled trial. Randomisation was stratified for sex, birth weight (<1250 vs ≥1250 g) and hospital. Setting: Five Australian tertiary hospitals from 2008 to 2013. Participants: 626 of the 657 participants randomised between 2001 and 2005 were eligible to participate. Interventions: High-DHA (≈1% total fatty acids) enteral feeds compared with standard-DHA (≈0.3% total fatty acids) from age 2-4 days ..
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Awarded by Mead Johnson Nutrition
Funding Acknowledgements
This work was supported by a 5-year project grant from the National Health and Medical Research Council (NHMRC), Australia (ID 508003) and Mead Johnson Nutrition. CTC is supported through a MS McLeod Postdoctoral Research Fellowship (MS McLeod Research Fund, Women's and Children's Hospital Research Foundation); NHMRC Fellowships support RAG (Senior Principal Research Fellow APP1046207), PJA (Senior Research Fellow APP628371), PGD (Practitioner Fellow APP1059111), PBC (Practitioner Fellow APP511117), MM (Principal Research Fellow APP1061704).