Journal article

A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases

Nikolai Dontschuk, Alastair Stacey, Anton Tadich, Kevin J Rietwyk, Alex Schenk, Mark T Edmonds, Olga Shimoni, Chris I Pakes, Steven Prawer, Jiri Cervenka

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2015

Abstract

Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conducta..

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Grants

Awarded by Australian Research Council


Funding Acknowledgements

This research was supported under Australian Research Council's Discovery Projects funding scheme (project number DE120101100). The authors acknowledge the facilities and the scientific assistance of the Soft X-ray beam line at the Australian Synchrotron, Victoria, Australia.