Journal article
Abnormal inhibition-excitation imbalance in migraine
Bao N Nguyen, Allison M McKendrick, Algis J Vingrys
CEPHALALGIA | SAGE PUBLICATIONS LTD | Published : 2016
Abstract
BACKGROUND: People with migraine show increased surround suppression of perceived contrast, a perceptual analogue of centre-surround antagonistic interactions in visual cortex. A proposed mechanism is that cortical 'hyperexcitability' or 'hyperresponsivity', a prominent theory in the migraine literature, drives abnormal excitatory-inhibitory balance to give increased local inhibition. The purpose of this cross-sectional study was to determine whether cortical hyperresponsivity and excitatory-inhibitory imbalance manifests in the visual cortical response of migraine sufferers. METHODS: Interictal steady-state visual evoked potentials (VEPs) in response to 0 to 97% contrast were recorded in 30..
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Awarded by National Health and Medical Research Council grant
Awarded by Australian Research Council grant
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council grant (number 509208) to A.M.M. and Australian Research Council grant (number FT0990930) to A.M.M. B.N.N. was supported by the Elizabeth and Vernon Puzey Postgraduate Scholarship from the Faculty of Science at the University of Melbourne.