Journal article
Long-term effect of goal-directed weight management in an atrial fibrillation cohort: A long-term follow-up study (LEGACY)
RK Pathak, ME Middeldorp, M Meredith, AB Mehta, R Mahajan, CX Wong, D Twomey, AD Elliott, JM Kalman, WP Abhayaratna, DH Lau, P Sanders
Journal of the American College of Cardiology | Published : 2015
Abstract
Background Obesity and atrial fibrillation (AF) frequently coexist. Weight loss reduces the burden of AF, but whether this is sustained, has a dose effect, or is influenced by weight fluctuation is unknown. Objectives This study sought to evaluate the long-term impact of weight loss and weight fluctuation on rhythm control in obese individuals with AF. Methods Of 1,415 consecutive patients with AF, 825 had a body mass index ≥27 kg/m2 and were offered weight management. After screening for exclusion criteria, 355 were included in this analysis. Weight loss was categorized as group 1 (≥10%), group 2 (3% to 9%), and group 3 (<3%). Weight trend and/or fluctuation was determined by yearly follow-..
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Funding Acknowledgements
This study was supported by the Centre for Heart Rhythm Disorders at the University of Adelaide, Adelaide, Australia. The sponsor has had no direct involvement in the design and conduct of the study, collection, management, analysis and interpretation of the data, preparation, review or approval of the paper, or the decision to submit the paper for publication. Dr. Pathak is supported by a Postgraduate Scholarship from the Lion's Medical Research Foundation and an Australian Postgraduate Award from the University of Adelaide. Drs. Pathak and Twomey are supported by Leo J. Mahar Electrophysiology Scholarships from the University of Adelaide. Dr. Wong is supported by a Rhodes scholarship and a Postgraduate Medical Scholarship from the National Health and Medical Research Council of Australia. Dr. Mahajan is supported by the Leo J. Mahar Lectureship from the University of Adelaide. Drs. Kalman and Sanders are supported by Practitioner Fellowships from the National Health and Medical Research Council of Australia. Drs. Abhayaratna and Sanders are supported by the National Heart Foundation of Australia. Dr. Lau is supported by a Postdoctoral Fellowship from the National Health and Medical Research Council of Australia. Dr. Kalman has received research funding from St. Jude Medical, Biosense-Webster, Medtronic, and Boston Scientific. Dr. Sanders has served on the advisory board of Biosense-Webster, Medtronic, St. Jude Medical, Sanofi, and Merck, Sharpe and Dohme; has received lecture and/or consulting fees from Biosense-Webster, Medtronic, St. Jude Medical, Boston Scientific, Merck, Sharpe and Dohme, Biotronik, and Sanofi; and has received research funding from Medtronic, St. Jude Medical, Boston Scientific, Biotronik, and Sorin. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.