Journal article
ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts
HM Sha'Ari, BS Haerian, L Baum, J Saruwatari, HJ Tan, MH Rafia, AA Raymond, P Kwan, T Ishitsu, K Nakagawa, KS Lim, Z Mohamed
Pharmacogenomics | FUTURE MEDICINE LTD | Published : 2014
DOI: 10.2217/pgs.13.239
Abstract
Aim: To examine the relevance of ABCC2 polymorphisms to drug responsiveness in epilepsy cohorts from the Asia Pacific region. Materials & methods: The rs2273697 and rs3740066 polymorphisms were genotyped in 2056 Malaysian (55%), Hong Kong (32%) and Japanese (13%) epilepsy patients. Results: Significant allele association of rs2273697 was observed in Chinese females with epilepsy, Malaysian Chinese patients with generalized seizure and Japanese patients with partial seizure for the AA versus GG genotype model and Malaysian Chinese patients with generalized seizure for the GA versus GG and autosomal dominant models. Significant association of the rs3740066 allele was observed in Malaysian fema..
View full abstractGrants
Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
This study was supported by grant HIR-MOHE E000025-20001, UM PPP grant (PV111/2011A) and RG520-13HTM from Malaysia, Research Grants Council of the Hong Kong Special Administrative Region from China (Project no. CUHK4466/06M) and research grant from Japan (KAKENHI no. 19590539, 16109006 and 22790161). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.