Journal article

Optimizing the Electrical Stimulation of Retinal Ganglion Cells

AE Hadjinicolaou, CO Savage, NV Apollo, DJ Garrett, SL Cloherty, MR Ibbotson, BJ O'Brien

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2015

Abstract

Epiretinal prostheses aim to restore visual perception in the blind through electrical stimulation of surviving retinal ganglion cells (RGCs). While the effects of several waveform parameters (e.g., phase duration) on stimulation efficacy have been described, their relative influence remains unclear. Further, morphological differences between RGC classes represent a key source of variability that has not been accounted for in previous studies. Here we investigate the effect of electrical stimulus waveform parameters on activation of an anatomically homogenous RGC population and describe a technique for identifying optimal stimulus parameters to minimize the required stimulus charge. Response..

View full abstract

Grants

Awarded by Australian Research Council


Awarded by Centre of Excellence in Vision Science


Awarded by Special Research Initiative in Bionic Vision Science and Technology (Bionic Vision Australia)


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This work was supported by the Australian Research Council through Discovery ProjectGrant DP0881247, by the Centre of Excellence in Vision Science under Grant CE0561903 by the Special Research Initiative in Bionic Vision Science and Technology (Bionic Vision Australia: SR1000005), and by the National Health and Medical Research Council of Australia Project Grant GNT0585440.