Journal article

Oro-facial granulomatosis--a clinical and pathological analysis.

D Wiesenfeld, MM Ferguson, DN Mitchell, DG MacDonald, C Scully, K Cochran, RI Russell

Q J Med | Published : 1985


A study of 60 patients with oro-facial granulomatosis has been conducted and the clinical presentation of this disorder defined. It encompasses the previously recognised clinical entities of Melkersson-Rosenthal syndrome and cheilitis granulomatosa. The pathological features of the disease are lymphoedema and the presence of multiple non-caseating giant cell granulomata. These granulomata are histologically indistinguishable from those found in both gastrointestinal Crohn's disease and systemic sarcoidosis. Within this series of patients, nine had evidence suggestive of gastrointestinal Crohn's disease, and in six this was confirmed. A diagnosis of sarcoidosis was made in a further two patie..

View full abstract

University of Melbourne Researchers