Journal article
The potential of induced pluripotent stem cells in models of neurological disorders: Implications on future therapy
JM Crook, G Wallace, E Tomaskovic-Crook
Expert Review of Neurotherapeutics | TAYLOR & FRANCIS LTD | Published : 2015
Abstract
There is an urgent need for new and advanced approaches to modeling the pathological mechanisms of complex human neurological disorders. This is underscored by the decline in pharmaceutical research and development efficiency resulting in a relative decrease in new drug launches in the last several decades. Induced pluripotent stem cells represent a new tool to overcome many of the shortcomings of conventional methods, enabling live human neural cell modeling of complex conditions relating to aberrant neurodevelopment, such as schizophrenia, epilepsy and autism as well as age-associated neurodegeneration. This review considers the current status of induced pluripotent stem cell-based modelin..
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Funding Acknowledgements
The authors wish to acknowledge financial support from the Australian Research Council (ARC) and the ARC Centre of Excellence for Electromaterials Science (ACES). G Wallace additionally acknowledges the support of the ARC through an ARC Laureate Fellowship. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.