Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Kyaw M Tun, Mallika Imwong, Khin M Lwin, Aye A Win, Tin M Hlaing, Thaung Hlaing, Khin Lin, Myat P Kyaw, Katherine Plewes, M Abut Faiz, Mehul Dhorda, Phaik Yeong Cheah, Sasithon Pukrittayakamee, Elizabeth A Ashley, Tim JC Anderson, Shalini Nair, Marina McDew-White, Jennifer A Flegg, Eric Pm Grist, Philippe Guerin Show all
LANCET INFECTIOUS DISEASES | ELSEVIER SCI LTD | Published : 2015
BACKGROUND: Emergence of artemisinin resistance in southeast Asia poses a serious threat to the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has transformed approaches to the monitoring of artemisinin resistance, allowing introduction of molecular surveillance in remote areas through analysis of DNA. We aimed to assess the spread of artemisinin-resistant P falciparum in Myanmar by determining the relative prevalence of P falciparum parasites carrying K13-propeller mutations. METHODS: We did this cross-sectional survey at malaria treatment centres at 55 sites in ten administrative regions in Myanmar, and in relevant border regions in Thailand and Bangladesh, be..View full abstract
Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme and the Bill & Melinda Gates Foundation.