Journal article

Optimal timing of oral fosfomycin administration for pre-prostate biopsy prophylaxis

Nathaniel J Rhodes, Bradley J Gardiner, Michael N Neely, M Lindsay Grayson, Andrew G Ellis, Nathan Lawrentschuk, Albert G Frauman, Kelly M Maxwell, Teresa R Zembower, Marc H Scheetz

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | OXFORD UNIV PRESS | Published : 2015

Abstract

OBJECTIVES: As the optimal administration time for fosfomycin peri-procedural prophylaxis is unclear, we sought to determine optimal administration times for fosfomycin peri-procedural prophylaxis. METHODS: Plasma, peripheral zone and transition zone fosfomycin concentrations were obtained from 26 subjects undergoing transurethral resection of the prostate (TURP), following a single oral dose of 3 g of fosfomycin. Population pharmacokinetic modelling was completed with the Nonparametric Adaptive Grid (NPAG) algorithm (Pmetrics package for R), with a four-compartment model. Plasma and tissue concentrations were simulated during the first 24 h post-dose, comparing these with EUCAST susceptibil..

View full abstract