Journal article

Cardiovascular Adverse Effects of Phenylephrine Eyedrops A Systematic Review and Meta-analysis

Bethany Stavert, Myra B McGuinness, C Alex Harper, Robyn H Guymer, Robert P Finger

JAMA OPHTHALMOLOGY | AMER MEDICAL ASSOC | Published : 2015

Abstract

IMPORTANCE: Topical phenylephrine hydrochloride is routinely administered with few safety precautions, but evidence regarding its systemic safety to date is controversial. As even short-term variations in 24-hour blood pressure (BP) and heart rate (HR) can adversely affect cardiovascular health, better evidence on phenylephrine's effects on HR and BP is required. OBJECTIVE: To perform a meta-analysis of available evidence regarding cardiovascular adverse effects of topical phenylephrine. DATA SOURCES: PubMed, MEDLINE, and the Cochrane Database of Systematic Reviews and Clinical Trials were searched for relevant literature from January 1, 1970, to January 1, 2014, using a combination of the f..

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Grants

Funding Acknowledgements

This work was supported by the Charles Viertel Charitable Foundation, the Lloyd and Kathleen Ansell Ophthalmology Foundation, and the Mankiewicz-Zelkin Fellowship of the University of Melbourne. Ms Stavert is supported by the Hector Maclean Scholarship from the Centre for Eye Research Australia. The Centre for Eye Research Australia receives operational infrastructure support from the Victorian government.