Journal article

Enriched environment and the effect of age on ischemic brain damage

Deborah M Saucier, Jerome Y Yager, Edward A Armstrong, Avril Keller, Sandy Shultz

BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 2007

Abstract

Stroke affects all age groups from the newborn to the elderly. Previous work from our laboratory has shown that despite a greater susceptibility to brain damage, the immature brain recovers more rapidly and to a greater extent than does the more mature nervous system. In the current study, we examined the influence of environmental enrichment on the effects of age on the brain damaging effects of stroke. Rats aged 10, 63, and 180 days received ischemic insults following stereotactic intra-cerebral injection of endothelin-1, and resulting in injury to the right middle cerebral artery territory. Rats were then housed in either environmentally enriched cages, or standard cages for 60 days, afte..

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