Journal article

Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms

Tim Ruder, Syed Abid Ali, Kiel Ormerod, Andreas Brust, Mary-Louise Roymanchadi, Sabatino Ventura, Eivind AB Undheim, Timothy NW Jackson, A Joffre Mercier, Glenn F King, Paul F Alewood, Bryan G Fry



It has been previously shown that octopus venoms contain novel tachykinin peptides that despite being isolated from an invertebrate, contain the motifs characteristic of vertebrate tachykinin peptides rather than being more like conventional invertebrate tachykinin peptides. Therefore, in this study we examined the effect of three variants of octopus venom tachykinin peptides on invertebrate and vertebrate tissues. While there were differential potencies between the three peptides, their relative effects were uniquely consistent between invertebrate and vertebrae tissue assays. The most potent form (OCT-TK-III) was not only the most anionically charged but also was the most structurally stab..

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Awarded by National Science and Engineering Research Council of Canada

Funding Acknowledgements

BGF was funded by an Australian Research Council Future Fellowship and by the University of Queensland. SAA was the recipient of postdoctoral fellowship (PDRF Phase II Batch-V) from Higher Education Commission (HEC Islamabad) Pakistan. TNWJ was funded by an Australian Postgraduate Award. EABU acknowledges funding from the University of Queensland (International Postgraduate Research Scholarship, UQ Centennial Scholarship, and UQ Advantage Top-Up Scholarship) and the Norwegian State Education Loans Fund. AJM was funded by the National Science and Engineering Research Council of Canada (46292); KGO was funded by the National Science and Engineering Research Council of Canada and a Queen Elizabeth II Scholarship in Science and Technology.