Lessons from the mouse: potential contribution of bystander lymphocyte activation by viruses to human type 1 diabetes
Jessica A Pane, Barbara S Coulson
DIABETOLOGIA | SPRINGER | Published : 2015
Viruses are considered to be potential key modulators of type 1 diabetes mellitus, with several possible mechanisms proposed for their modes of action. Here we discuss the evidence for virus involvement, including pancreatic infection and the induction of T cell-mediated molecular mimicry. A particular focus of this review is the further possibility that virus infection triggers bystander activation of pre-existing autoreactive lymphocytes. In this scenario, the virus triggers dendritic cell maturation and proinflammatory cytokine secretion by engaging pattern recognition receptors. These proinflammatory cytokines provoke bystander autoreactive lymphocyte activation in the presence of cognat..View full abstract
Awarded by BSC's laboratory
Awarded by National Health and Medical Research Council of Australia
Work in BSC's laboratory is supported by Project Grants (APP1044868 and APP1085596) and Senior Research Fellowship ID628319 to BSC from the National Health and Medical Research Council of Australia.