Journal article

Factors Influencing the Formation of Single-Chain Polymeric Nanoparticles Prepared via Ring-Opening Polymerization

Edgar HH Wong, Greg G Qiao



The development of single-chain polymeric nanoparticles (SCNP) has been of great scientific interest in recent years. Recently, we have developed a robust system to form SCNP at high polymer concentration (ca. 100 mg mL-1) via organocatalyzed ring-opening polymerization (ROP). In this approach, linear polymer precursors functionalized with pendent polymerizable caprolactone moieties undergo self-cross-linking in the presence of organocatalyst and alcohol initiator. Following on from our previous communication, we report in here a more in-depth fundamental investigation to better understand our system. For this, we have synthesized various linear random copolymer precursors (i.e., poly(oligo(..

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University of Melbourne Researchers


Awarded by Australian Research Council

Funding Acknowledgements

The authors acknowledge the Australian Research Council under the Future Fellowship scheme (FT110100411, G.G.Q) for financial support of this work. E.H.H.W. acknowledges the receipt of a 2014 Early Career Researcher Grant from The University of Melbourne. The authors thank Dr. Jing M. Ren for valuable discussions.