Factors Influencing the Formation of Single-Chain Polymeric Nanoparticles Prepared via Ring-Opening Polymerization
Edgar HH Wong, Greg G Qiao
MACROMOLECULES | AMER CHEMICAL SOC | Published : 2015
The development of single-chain polymeric nanoparticles (SCNP) has been of great scientific interest in recent years. Recently, we have developed a robust system to form SCNP at high polymer concentration (ca. 100 mg mL-1) via organocatalyzed ring-opening polymerization (ROP). In this approach, linear polymer precursors functionalized with pendent polymerizable caprolactone moieties undergo self-cross-linking in the presence of organocatalyst and alcohol initiator. Following on from our previous communication, we report in here a more in-depth fundamental investigation to better understand our system. For this, we have synthesized various linear random copolymer precursors (i.e., poly(oligo(..View full abstract
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Awarded by Australian Research Council
The authors acknowledge the Australian Research Council under the Future Fellowship scheme (FT110100411, G.G.Q) for financial support of this work. E.H.H.W. acknowledges the receipt of a 2014 Early Career Researcher Grant from The University of Melbourne. The authors thank Dr. Jing M. Ren for valuable discussions.