Intracellular Growth Is Dependent on Tyrosine Catabolism in the Dimorphic Fungal Pathogen Penicillium marneffei
Kylie J Boyce, Alisha McLauchlan, Lena Schreider, Alex Andrianopoulos
PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2015
During infection, pathogens must utilise the available nutrient sources in order to grow while simultaneously evading or tolerating the host's defence systems. Amino acids are an important nutritional source for pathogenic fungi and can be assimilated from host proteins to provide both carbon and nitrogen. The hpdA gene of the dimorphic fungus Penicillium marneffei, which encodes an enzyme which catalyses the second step of tyrosine catabolism, was identified as up-regulated in pathogenic yeast cells. As well as enabling the fungus to acquire carbon and nitrogen, tyrosine is also a precursor in the formation of two types of protective melanin; DOPA melanin and pyomelanin. Chemical inhibition..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was funded by the National Health and Medical Research Council of Australia https://www.nhmrc.gov.au/ with grants 566926 to AA and 1006839 to AA and KJB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.